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Hydroxychloroquine Cuts Covid 19 Mortality by 50%

Jimbojolly

Posted 6:59 am, 07/05/2020

There are several high-quality studies that are designed to randomly assign patients to get either the malaria drugs or a placebo in which both the doctors and the patients don't know which one they are using. These trials are being run by the Swiss pharma giant Novartis, the University of Oxford, and the Bill and Melinda Gates Foundation.

antithesis

Posted 2:09 am, 07/05/2020

But as I said numerous times, they compared a mere 147 people in Group A to 1,202 in Group B.

And what was dangerous was Trump announcing it as a cure when there had been absolutely no studies done, in an apparent attempt to make his buddy and political donor even richer...

The Times reported that one of Sanofi's largest shareholders is Fisher Asset Management, a fund set up by political donor Ken Fisher, who has a history of donations to the GOP and contributed to Trump's 2016 campaign, according to NBC.

His shares would be worth about $775 million.

...

President Donald Trump has repeatedly endorsed chloroquine and hydroxychloroquine as experimental treatments to fight COVID-19, the disease caused by the new coronavirus, starting around March 21.

Since then, Sanofi's share price has risen around 16%, from $78.67 at market close on March 20 to $91.12 at time of publication on April 7.


So as of April 7 (a few days after Trump's unsubstantiated announcement), this GOP contributor had profited an additional $12.4 million.

And it's obvious that this highly skewed and flawed study has no purpose but to further validate that baseless claim.

sparkling water

Posted 12:51 am, 07/05/2020

Doesn't matter what you compare it to. If hydroxyckoroquine is as ineffectual and dangerous as leftists say, the results would show as many or more deaths.

antithesis

Posted 12:11 am, 07/05/2020

Their conclusion os that fewer people died while taking the drug.


... as compared to taking an anti-bacterial drug used to treat pink eye, that has no FDA approval to be used for COVID.

I'm sure they would have had the same results if they had compared hydroxychloroquine to almond milk.

sparkling water

Posted 6:04 pm, 07/04/2020

Their conclusion os that fewer people died while taking the drug.

The 13% difference would probably choose the drug if they had it to do again and had a choice.

I would take the drug and I suspect you would also if you were infected and in an ICU.

antithesis

Posted 5:35 pm, 07/04/2020

They don't need me to, Sparkles, their conclusion says the same thing that I said. You just have to read it.

sparkling water

Posted 5:29 pm, 07/04/2020

If only the study authors had anti to interpret their data for them.

antithesis

Posted 5:25 pm, 07/04/2020

I don't know how I said anything that opposes that, Tilly. My argument is that, since neither drug is FDA approved for COVID, it makes no sense to compare them. And it makes less sense to conclude that, since one unapproved drug worked better than the other unapproved drug, then (somehow?) the second drug "cuts mortality by 50%."

And, as I said before, when Group A only has 147 subjects while Group B has 1,202, it's not an apples-to-apples comparison.

And, as I also said before, vitamin D has been shown to have a bigger impact on COVID mortality than either of these unapproved drugs.

Sparkles, it has nothing to do with politics (although I would question why hydroxychloroquine is even being considered if not for politics), it's just common sense. This is a misleading study.

sparkling water

Posted 4:34 pm, 07/04/2020

I wonder how many of these leftists would say no if their Dr. prescribed the hydroxychloroquine?

sparkling water

Posted 4:32 pm, 07/04/2020

That's what happens when your first filter is political.

Tilly22

Posted 4:29 pm, 07/04/2020

No Anti, you are the one that doesn't understand, 26.4 percent of the patients not treated with either drug died, compared to 13 percent treated with hydrxoychloroquine alone.

In a large-scale retrospective analysis of 2,541 patients hospitalized between March 10 and May 2, 2020 across the system's six hospitals, the study found 13% of those treated with hydroxychloroquine alone died compared to 26.4% not treated with hydroxychloroquine. None of the patients had documented serious heart abnormalities; however, patients were monitored for a heart condition routinely pointed to as a reason to avoid the drug as a treatment for COVID-19.

They also gave the drug soon after a hospital admission, they didn't wait until someone is on death's door to administer it:

The vast majority received the drug soon after admission; 82% within 24 hours and 91% within 48 hours of admission. https://www.henryford.com/n...ment-study

antithesis

Posted 3:09 pm, 07/04/2020

You misunderstand, sparkles (and Tilly).

This study compared one drug that's not FDA approved to treat COVID to another drug that's not FDA approved to treat COVID. They may as well have done a study comparing the use of orange juice to a multivitamin.

In fact, that would actually have been a better study... vitamin D apparently has a bigger affect on COVID mortality than either of these drugs:


I would also question whether the study is even fair, considering they testing 1,202 people with hydroxychloroquine and only 147 with azithromycin. A fair comparison would have had an even number of participants on both sides... too many other factors can affect that small of a comparison group (history of diet, exercise, drug usage, etc).

sparkling water

Posted 2:16 pm, 07/04/2020

This one passed the peer review process.


Why do leftists hate science??????

Jimbojolly

Posted 1:41 pm, 07/04/2020

skeptic, you are the one lying. "The media" didn't make any claims, however there were a number of medical trials and evaluations that contradicted this one, basically stating anecdotal results.

The trial done on veterans cited more deaths because of the drug.

skeptic

Posted 10:59 am, 07/04/2020

This can't be true. All the media said Trump was lying. Lol. I guess they are wrong yet again.

Tilly22

Posted 8:23 am, 07/04/2020

Is 13 not half of 26?


Also in a study less than have the size of this one, Remdesivir cut the mortality rate from 11.9 to 7.1 but with a price of $3120.

Remdesivir's effectiveness against Covid-19 was established in a 1,063-patient study conducted by the National Institute of Allergy and Infectious Diseases. In results released in late April and later published in the New England Journal of Medicine, the drug reduced the median time it took a patient to recover from 15 days to 11 days with a 10 day course of treatment. The mortality rate in the remdesivir group was 7.1%, compared to 11.9% among those who received placebo, but the difference was not statistically significant. In another study in less sick patients, remdesivir led patients to improve more than placebo when it was given for five days, but not when it was given for 10.

sparkling water

Posted 8:21 am, 07/04/2020

Anti, you are engaged in misleading behavior.

You depend on less knowledgeable people being awed by your medical familiarity and assuming you have presented information in a neutral manner. Obviously, that is not the case.

sparkling water

Posted 8:19 am, 07/04/2020

From your medical news today article:


UNDER STUDY FOR COVID-19

Azithromycin has been studied as part of a possible treatment combination for COVID-19. This is the illness caused by the new coronavirus. It is not known if this drug is effective for treating COVID-19, and it is not FDA-approved for this use.

For current information about the COVID-19 outbreak, explore our live updates. And for information on how to prepare, advice on prevention and treatment, and expert recommendations, visit our coronavirus hub.

sparkling water

Posted 8:17 am, 07/04/2020

From your drugs.com article:


Azithromycin may also be used for purposes not listed in this medication guide.

sparkling water

Posted 8:16 am, 07/04/2020

From your ijid article


Conclusions and Relevance

In this multi-hospital assessment, when controlling for COVID-19 risk factors, treatment with hydroxychloroquine alone and in combination with azithromycin was associated with reduction in COVID-19 associated mortality. Prospective trials are needed to examine this impact.

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